Manufacturers indicate that angiotensin receptor blockers (ARBs) may be administered with or without food, and there are no food contraindications or interactions noted.1-9
Valsartan is the only ARB that is affected by food. Food may decrease the rate and extent of valsartan absorption by about 40%.9-12 However, the manufacturers state that the drug can be taken without regard to food.9
- Benicar [package insert] Parsippany, NJ: Daiichi Sankyo, Inc; 2009.
- Micardis [package insert] Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc. ; 2014.
- Teveten [package insert]. North Chicago, IL: AbbVie Inc.; 2014.
- Cozaar [package insert]. Whitehouse Station, NJ: Merck Sharp & Dohme Corp; 2015.
- Avapro [package insert] Bridgewater, NJ: Sanofi-Aventis U.S. LLC 2016.
- Atacand [package insert] Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2016.
- Edarbi [package insert] Atlanta, GA: Arbor Pharmaceuticals, LLC; 2016.
- AHFS drug information. Gerald K. McEvoy PD, ed. 24:32.08 Angiotensin II Receptor Antagonists. 59th ed. Bethesda, MD: American Society of Health-System Pharmacists; 2017.
- Diovan [package insert] East Hanover, NJ: Novartis Pharmaceuticals Corp; 2017.
- Chiolero A, Burnier M. Pharmacology of valsartan, an angiotensin II receptor antagonist. Expert Opin Investig Drugs 1998; 7 (11): 1915-1925.
- Israili ZH. Clinical pharmacokinetics of angiotensin II (AT1) receptor blockers in hypertension. J Hum Hypertens 2000; 14 Suppl 1: S73-86.
- Michel MC, Foster C, Brunner HR, Liu L. A systematic comparison of the properties of clinically used angiotensin II type 1 receptor antagonists. Pharmacol Rev 2013; 65 (2): 809-848.