Yes, there are some medicines you might want to avoid if you are taking chlorthalidone. Most doctors recommend not taking dofetilide, mecamylamine, promazine, and lithium with chlorthalidone.

  • Dofetilide is used to control heart rhythm. It can cause an abnormal heartbeat when taken with chlorthalidone.
  • Mecamylamine is used to control high blood pressure. It has also been used to help smokers quit. Chlorthalidone can increase the effects of mecamylamine. This can be dangerous.
  • Promazine is used to control mental health disorders. Taking promazine with chlorthalidone can cause an abnormal heartbeat.
  • Lithium is used to control mood swings in people with conditions like bipolar disorder. Taking chlorthalidone with lithium can cause dangerous levels of lithium in the body.

This list does not include all the medicines that could cause problems when mixed with chlorthalidone.

Chlorthalidone can lower blood levels of potassium, sodium, and magnesium. Because of this, you may need to be careful when mixing chlorthalidone with other medicines that affect these levels.

Chlorthalidone can also change the way your body gets rid of medicines. This may mean the dose of other medicines should change if you start chlorthalidone. The only way to know for sure is to talk to your doctor or pharmacist about all the medicines you take to be sure they are safe to take together.

Keep yourself safe – tell your doctor what you take!