Can I go out in the sun while taking an angiotensin-converting enzyme (ACE) inhibitor?

Photosensitivity reactions have been reported as a rare side effect for some angiotensin-converting enzyme (ACE) inhibitors including benazepril, enalapril, fosinopril, lisinopril, quinapril, and ramipril.^1-6

No systematic review of the literature has been published. Only case reports of photosensitivity reactions to ACE inhibitors are available.^7-11

No restrictions to sun exposure are suggested by manufacturers.^1-6,12-15

^References

1. Prinivil [package insert]. Whitehouse Station, NJ: Merck Sharp & Dohme Corp.; 2016.
2. Fosinopril sodium [package insert]. Miami, FL: Ciplo USA Inc; 2015.
3. Altace [package insert]. New York, NY: Pfizer Laboratories; 2017.
4. Lotensin [package insert]. Parsippany, NJ: Validus Pharmaceuticals LLC; 2014.
5. Vasotec [package insert]. Bridgewater, NJ: Valeant Pharmaceuticals North America LLC; 2015.
6. Accupril [package insert]. New York, NY: Parke Davis, Pfizer; 2017.
7. Sanchez-Borges M, Gonzalez-Aveledo LA. Photoallergic reactions to angiotensin converting enzyme inhibitors. J Eur Acad Dermatol Venereol 2011; 25 (5): 621-622.
8. Rodriguez Granados MT, Abalde T, Garcia Doval I, De la Torre C. Systemic photosensitivity to quinapril. J Eur Acad Dermatol Venereol 2004; 18 (3): 389-390.
9. Steckelings UM, Artuc M, Wollschlager T, Wiehstutz S, Henz BM. Angiotensin-converting enzyme inhibitors as inducers of adverse cutaneous reactions. Acta Derm Venereol 2001; 81 (5): 321-325.
10. Wagner SN, Welke F, Goos M. Occupational UVA-induced allergic photodermatitis in a welder due to hydrochlorothiazide and ramipril. Contact Dermatitis 2000; 43 (4): 245-246.
11. Mauduit G, Granier F, Antoniotti O, Thivolet J. Photosensitivity after treatment with captopril. Ann Dermatol Venereol 1988; 115 (2): 167-169.
12. Trandolapril [package insert]. Laurelton, NY: Epic Pharma, LLC; 2017.
13. Moexipril hydrochloride [package insert]. Teva Pharmaceuticals USA Inc; 2016.
14. Aceon [package insert]. North Chicago, IL: Abbot Laboratories; 2011.
15. Capoten [package insert]. Spring Valley, NY: Par Pharmaceutical Companies, Inc.; 2012.