Thiazide diuretics are a commonly prescribed class of antihypertensives in the US, and hydrochlorothiazide (HCTZ) is the most commonly prescribed thiazide.1-3 Hwang et al. analyzed antihypertensive drug trends from 2008 to 2014 using prescription claims data from the Marketscan database.2 The Marketscan database represents nearly 55% of employer-based insurance programs, covering nearly 30 million Americans.4 Adults between the ages of 18 and 65 with an International Classification of Diseases (ICD) code of hypertension were included in the analysis.2 In 2014, HCTZ made up 92.9% of thiazide diuretics being used.2 Analyses of antihypertensive drug trends, both using National Health and Nutrition Examination Surveys (NHANES) data, also found hydrochlorothiazide to be the most widely used diuretic.1,3
HCTZ used as monotherapy increased 3.4% from 2001 to 2010.1 The use of HCTZ in combination with other antihypertensives also increased over this period.
49 million prescriptions were written for HCTZ in the US in 2016.5
- Gu Q, Burt VL, Dillon CF, Yoon S. Trends in antihypertensive medication use and blood pressure control among United States adults with hypertension: the National Health And Nutrition Examination Survey, 2001 to 2010. Circulation 2012; 126 (17): 2105-2114.
- Hwang AY, Dave C, Smith SM. Trends in Antihypertensive Medication Use Among US Patients With Resistant Hypertension, 2008 to 2014. Hypertension 2016; 68 (6): 1349-1354.
- Kantor ED, Rehm CD, Haas JS, Chan AT, Giovannucci EL. Trends in Prescription Drug Use Among Adults in the United States From 1999-2012. JAMA 2015; 314 (17): 1818-1831.
- Smith JC, Medalia C. Health Insurance Coverage in the United States: 2014. Washington, D.C.: U.S. Census Bureau; 2015.
- Aitken M, Kleinrock M. Medicines Use and Spending in the U.S.: A Review of 2016 and Outlook to 2021. 2017.