You can take amlodipine with or without food. The most important thing is to take amlodipine at a time of day that helps you to remember to take it. Some people find it easiest to remember if they take their pills with a meal.
If you take amlodipine as a combination pill, check with your doctor. Food might affect the other drugs in the pill.
Grapefruit juice may affect amlodipine. To be on the safe side, limit yourself to one glass of grapefruit juice a day.