Manufacturer’s prescribing information does not mention any contraindications for the use of spironolactone based on allergies.1
Allergic reactions in persons taking spironolactone and apparent spironolactone intolerance have rarely been reported in the literature.2–10 Evidence of sensitivity to spironolactone included multisystem failure, skin reactions (erythema multiforme, bullous pemphigoid, contact dermatitis, lichenoid skin eruptions, maculopapular and erythematous rashes, urticaria), Stevens Johnson syndrome, eosinophilia, vasculitis, and anaphylaxis.
- Aldactone-spironolactone prescribing information. New York, NY: Searle LLC Division of Pfizer, Inc; 2016.
- Wathen CG, MacDonald T, Wise LA, Boyd SM. Eosinophilia associated with spironolactone. Lancet 1986; 1 (8486): 919-920.
- Gupta AK, Knowles SR, Shear NH. Spironolactone-associated cutaneous effects: a case report and a review of the literature. Dermatology 1994; 189 (4): 402-405.
- Aguirre A, Manzano D, Zabala R, Eizaguirre X, Diaz-Perez JL. Allergic contact dermatitis from spironolactone. Contact Dermatitis 1994; 30 (5): 312.
- Schon MP, Tebbe B, Trautmann C, Orfanos CE. Lichenoid drug eruption induced by spironolactone. Acta Derm Venereol 1994; 74 (6): 476.
- Modeste AB, Cordel N, Courville P, Gilbert D, Lauret P, Joly P. [Bullous pemphigoid induced by spironolactone]. Ann Dermatol Venereol 2002; 129 (1 Pt 1): 56-58.
- Alonso JCM, Ortega FJD, Gonzalo MJF, Palla PS. Cutaneous reaction to oral spironolactone with positive patch test. Contact Dermatitis 2002; 47 (3): 178-179.
- Ghislain P-D, Bodarwe A-D, Vanderdonckt O, Tennstedt D, Marot L, Lachapelle J-M. Drug-induced eosinophilia and multisystemic failure with positive patch-test reaction to spironolactone: DRESS syndrome. Acta Derm Venereol 2004; 84 (1): 65-68.
- Greenberger PA, Lazar HP. Readministration of spironolactone in the spironolactone-intolerant patient. N Engl Reg Allergy Proc 1986; 7 (4): 343-345.
- McEvoy G, Spironolactone, AHFS Drug Information 2007. Bethesda, MD