Some of the more common side effects that can happen with spironolactone are:

  • Fatigue
  • Headache
  • Dizziness
  • Lightheadedness
  • Nausea
  • Diarrhea
  • Vomiting
  • High levels of potassium

Some men may notice:

  • Enlarged breast tissue (gynecomastia)
  • Impotence (erectile dysfunction)
  • A decrease in sex drive

Some women may notice:

  • Irregular or abnormal periods
  • Their period stop completely

These problems usually go away if the drug is stopped.

Be sure to contact your doctor if you develop any side effects. Your doctor can help you decide if spironolactone is still the best option for you.